Symptom orientation: Fibromyalgia - A collection of scientific studies!

CONTENT

1. Symptom orientation!
2. Autism!
3. Cancer!
4. Fibromyalgia!
5. Psoriasis!
6. Multiple Sclerosis!
7. Osteomalacia!
8. More about VitaminD!

1. Symptom orientation!

General view on distraction from solutions by declaring the symptoms of the diseases to be their reasons.
https://geoarchitektur.blogspot.com/p/symptom-orientation-autism-cancer.html

Chapters of this article have been put into separate pages, but the content list and numbering of the chapters ist kept as original.

2. Autism!

Symptom orientation: Autism - A collection of scientific studies!
https://geoarchitektur.blogspot.com/p/symptom-orientation-autism-collection.html


3. Cancer

Symptom orientation: Cancer - A collection of scientific studies!

https://geoarchitektur.blogspot.com/p/symptom-orientation-cancer-collection.html

4. Fibromyalgia!

Let us begin with some basics.

Fibromyalgia Syndrome
http://www.fibromyalgia-symptoms.org/fibromyalgia_syndrome.html

"Fibromyalgia is a chronic illness that causes immense physical pain and debilitating fatigue. Classified as a syndrome, fibromyalgia is not a disease. Instead it is a condition that causes many different symptoms. These symptoms affect all systems in the body. Fibromyalgia plagues up to 5% of the population, with 6 million sufferers in the United States alone. The name fibromyalgia comes from \"fibro\" meaning fibrous tissue (such as tendons and ligaments), \"my\" meaning muscles, and \"algia\" meaning pain."

"Many Other Symptoms
Although pain is the foremost symptom of fibromyalgia, it is by no means the only symptom. Among other symptoms, fibromyalgia sufferers often experience:

• sleep disorders
• fatigue
• morning stiffness
• irritable bowel syndrome

"

The so called "research" is again prepoccupied with the symptoms and doesn't really deliver any reason!

What Is The Latest Fibromyalgia Research?
http://www.fibromyalgia-symptoms.org/fibromyalgia-research.html

"

• Processing Pain
• Genetics
• Stress
• Reproductive Hormones
• Sleep Problems
• Psychiatric Disorders
• Understanding Different Reactions To Fibromyalgia

"

Vitamin D May Ease Fibro Pain
By Randy Dotinga, HealthDay Reporter
http://www.webmd.com/fibromyalgia/news/20140117/vitamin-d-supplements-may-help-ease-fibromyalgia-pain-study

"In the study, researchers led by Dr. Florian Wepner, of Orthopedic Hospital Vienna Speising, sought to discover whether there is a link between a patient's vitamin D levels and the chronic pain of fibromyalgia."

"Wepner's team launched a randomized, controlled trial in 30 women with fibromyalgia who also had low levels of vitamin D. Some of the women took supplements for 25 weeks and then were tracked for another 24 weeks."

"Reporting in the February issue of the journal Pain, the researchers said those who took supplements reported less pain and morning fatigue over time than those who did not receive the supplements."

"[Vitamin D] may be regarded as a relatively safe and economical treatment and an extremely cost-effective alternative or adjunct to expensive pharmacological treatment," Wepner said in a journal news release."

"Vitamin D levels should be monitored in fibromyalgia patients -- especially in the winter when levels can be lower due to less sun exposure -- and adjusted as necessary, Wepner said."

"Although the study was able to find an association between vitamin D supplementation and an easing of fibromyalgia pain, it did not prove a cause-and-effect link."

"Fibromyalgia patients and those with chronic pain should certainly have their vitamin D blood levels checked and, if low, consider supplementation under the guidance of a physician," said Dr. Kiran Patel, a pain medicine specialist at Lenox Hill Hospital in New York City who often treats people with fibromyalgia."

"Dr. Houman Danesh, director of integrative pain management at Mount Sinai Hospital in New York City, agreed. "Vitamin D deficiency has been linked to chronic pain, and this study further strengthens the argument to [replenish] vitamin D in deficient individuals," he said."

""It is important to note that these patients were under the care of a physician during the [vitamin] repletion, and that it took months for the benefits to be shown," Danesh said. "This is expected, as vitamin D is a fat-soluble vitamin and is stored in fat cells. When a patient has low levels, those stores need to be [replenished], and this takes weeks or months to occur.""

Here is a more mixed view on VitaminD and fibromyalgia!

Fibromyalgia: Vitamin D and fibromyalgia
https://www.vitamindcouncil.org/health-conditions/fibromyalgia/

"Vitamin D levels

Several studies report that people with fibromyalgia have lower vitamin D levels:

In the United Kingdom, 43% of females with fibromyalgia had very low vitamin D levels compared to 19% without fibromyalgia.
In Belfast, Northern Ireland, people with fibromyalgia frequently had low vitamin D levels. The study also linked anxiety and depression to low vitamin D levels.

However, other studies have different observations:

In Israel and Brazil, vitamin D levels did not vary in people with or without fibromyalgia. In the same Brazilian study, there was no connection between vitamin D levels and pain intensity.

In Turkey, neither vitamin D levels nor bone mineral density varied in people with or without fibromyalgia.

In all of the above studies, vitamin D levels could be the result of disease condition rather than the cause of the disease. Thus, the evidence that vitamin D plays a role in fibromyalgia is weak at best."

"How vitamin D works

Some studies have reported that vitamin D may reduce the risk or symptoms of fibromyalgia by lowering inflammation. Vitamin D reduces cytokine production. This protein causes inflammation. However, one study found that fibromyalgia pain was not directly affected by these compounds."

"Prevention

There is no evidence that vitamin D reduces the risk of fibromyalgia. However, it may reduce inflammation. Based on studies of other diseases, it might be worthwhile to keep vitamin D blood levels above 30–40 ng/mL (75–100 nmol/L)."

"Treatment

Vitamin D has been used to treat fibromyalgia in several studies and observations:

In the United Arab Emirates, people diagnosed with fibromyalgia or muscle pain benefited from vitamin D. However, it was unclear whether those with muscle pain actually had fibromyalgia.

People in Minnesota with fibromyalgia who initially had low vitamin D levels (10–25 ng/mL [25–63 nmol/L]) participated in a clinical trial. Some people received placebos. Others took 7000 international units (IU)/day of vitamin D3 (cholecalciferol). Vitamin D3 is the type of vitamin D made in the body.

After 8 weeks, those receiving placebos showed no improvement. The vitamin D3 group showed significant improvement in fibromyalgia assessment scores. However, they did not show significant improvement in most musculoskeletal symptoms or in activities of daily living. In addition, those with severe vitamin D deficiency had no symptom improvement during the trial nor one year later."

"Diffuse back pain related to vitamin D deficiency is often diagnosed as fibromyalgia. Raising vitamin D blood levels reduces that type of pain."

"Vitamin D may reduce fibromyalgia pain. Those with fibromyalgia should consider increasing their vitamin D levels above 30–40 ng/mL (75–100 nmol/L)."

Does anyone ask why the people suffer vitaminD-deficiency and how long?

Which impact would long term vitaminD-deficiency have on human body?

Aren't women more dependent on vitaminD because of monthly menstruation?

Just look here! It touches the explanation of cancer again, but more is told about the requirement of vitaminD for a healthy life, particularly for the pregnant mother and her growing baby.

Journal of Reproductive Medicine and Endocrinology

Vitamin D: What Gynecologists Need to Know.
http://h1707126.stratoserver.net/kup/pdf/10329.pdf

"Vitamin D is classically known to protect against rickets and is a standard treatment for osteoporosis patients. Vitamin D receptors (VDR) have, however, been discovered in almost all human cells and recent studies suggest an important role of the vitamin D endocrine system for several extraskeletal diseases."

"In detail, we discuss that vitamin D deficiency is associated with increased risk of adverse pregnancy outcomes, reduced fertility and polycystic ovary syndrome (PCOS), as well as cancer."

The rest is in German and will be directly translated here!

"Solch ein Mangel an Vitamin D findet sich bei ca. der Hälfte der deutschen und österreichischen Allgemeinbevölkerung, wobei dies zu ausgeprägten gesundheitlichen Folgen führen kann, da der Vitamin-D-Rezeptor (VDR) in fast allen Zellen des menschlichen Körpers exprimiert wird und das Vitamin D und seine Metaboliten ca. 3 % der menschlichen Genoms regulieren."

[Such a deficiency of vitaminD can be found at about the half of German and Austrian population, where this can lead to distinct health issues, as the vitaminD receptor (VDR) is shown in nearly all cell types of human body and vitaminD and its metabolites regulate about 3% of human genome.]

"Daher ist es nicht verwunderlich, dass Vitamin D bei sehr vielen Erkrankungen eine Rolle spielt, wobei Vitamin D schon seit Jahren eine Standardtherapie bei Osteoporose-Patienten ist, da Vitamin-D-Supplementierung die Häufigkeit von Stürzen und Knochenbrüchen signifikant reduziert."

[Therefore it doesn't surprise that vitaminD has a role in many diseases, where vitaminD is already a therapy for osteoporosis, as supplementing vitaminD significantly reduces the frequency of tumbling and broken bones.]

"Zahlreiche Studien weisen auch daraufhin, dass Vitamin D bei diversen anderen Erkrankungen wie z. B. Herz-Kreislauferkrankungen, Infektions- oder Autoimmunerkrankungen sowie Krebs eine positive Rolle spielen könnte."

[Many studies also indicate that vitaminD has positive role in many other diseases, like heart-blood-circulation, infections or auto immune disorders as well as cancer.]

"Dies wird auch dadurch unterstrichen, dass eine Meta-Analyse von randomisierten, placebokontrollierten Studien zeigen konnte, dass Personen, welche Vitamin D einnehmen, statistisch signifikant länger leben."

[This is also emphasized, as show by a meta analysis of randomized, placebo controlled studies, that people taking vitaminD live statistically longer.]

"Das im Serum zirkulierende 25(OH)D scheint die entscheidende Determinante für die lokale 1,25(OH)2D Bildung in den extra-renalen Geweben zu sein, während die 1,25(OH)2D Bildung in der Niere vor allem durch den Kalzium-Phosphathaushalt beeinflusst wird."

[The 25(OH)D circulating in the serum, seems to be the decisive determinant for the local bildup of 1.25(OH)2D in the extra-renal tissues, where the 1.25(OH)2D buildup is influenced in the kindeys, mainly by calcium-phosphate balance.]

"Gerade in der Schwangerschaft scheint ein suffizienter Vitamin-D-Status von besonderer Bedeutung für Mutter und Kind zu sein, wobei hier das 25(OH)D von der Mutter in den kindlichen Kreislauf gelangt."

[Particularly during pregnancy, a sufficient vitaminD condition seems to be very important for mother and child, where the 25(OH)D is transferred from the mother to the circulation of the child.]

"Die offiziellen Empfehlungen für die Vitamin-D-Einnahme bei Schwangeren schwanken zwischen Minimalmengen von 200–400 IE pro Tag bis hin zu etwa 2000 IE tgl. (z. B. in Kanada)."

[The minimal recommended amount of vitaminD supplementation varies between 200 and 400 IU per day up to about 2000 IU daily (e.g. in Canada).]

"Eine bereits auf diversen Kongressen präsentierte Studie von Bruce Hollis (USA) konnte zeigen, dass die Einnahme von 4000 IE während der Schwangerschaft nicht nur absolut nebenwirkungsfrei ist, sondern auch die Rate an Frühgeburten bzw. Schwangerschaftskomplikationen reduziert."

[A study presented in various conferences by Bruce Hollis (USA) could show that taking of 4000 IU during pregnancy is not only free of side effects, but also reduces the rate of premature birth and complications during pregnancy.]

"Hier hat neben der „Endocrine Society Practice Guideline“ z. B. Ende 2010 das „Institute of Medicine“ (IOM) in den USA eine tägliche Einnahme von zumindest 600 IE Vitamin D (vormals waren es nur 200 IE) und einen 25(OH)D-Spiegel von zumindest 20 ng/mL (50 nmol/L) für schwangere Frauen empfohlen, mit dem Hinweis, dass bis zu 4000 IE tgl. in der Schwangerschaft (entsprechend der von Bruce Hollis empfohlenen Dosis, welche jedoch derzeit von keiner großen Fachgesellschaft unterstützt wird) als sicher zu werten sind."

[Parallel to the 'Endocrine Society Practice Guideline' the 'Institute of Medicine' (IOM) in the USA has recommended a daily take of 600 IU vitaminD (before it was 200 IU) and a 25(OH)D level of minimum 20nq/mL (50 nmol/L) for pregnant women, with a notice about 4000 IU daily during pregnancy (according the dose recommended by Bruce Hollis, which is not supported by any medical association yet) would be considered as safe.]

"Weiters wurde beobachtet, dass weibliche VDR-Knock-out-Mäuse eine uterine Hypoplasie, eine gestörte ovarielle Follikulogenese sowie eine um 75 % reduzierte Fertilität aufwiesen."

[Further it was observed that female VDR knockout mice develop an uterine hypoplasia, a disordered ovarial folliculagenesis as well as 75% reduction of fertilitiy.]

"Interessanterweise zeigen auch männliche VDR-Knockout-Mäuse eine reduzierte Fertilität mit Hypogonadismus und gestörter Spermiogenese [4]. Klinische Studien beim Menschen zeigen bei Männern in manchen, aber nicht allen Studien einen Zusammenhang zwischen höheren 25(OH)D-Spiegeln und besserer Spermienqualität sowie höheren Testosteronwerten."

[Interestingly, also the male VDR knockout mice show a reduced fertility with hypogonadism and disordered spermiogenesia. Clinicial studies with people show by men, in some but not all studies, a correlation between higher 25(OH)D level and improved quality of sperms and higher testosterone degrees.]

"Bereits Anfang des 20. Jahrhunderts wurde beobachtet, dass Patienten mit Hautkrebs bzw. starker Sonneneinstrahlung ein signifikant reduziertes Risiko für Krebsmortalität bzw. Krebsinzidenz aufwiesen"

[Already at the beginning of 20th century it was observed, that patients with skin cancer and higher sunlight radiation have a significantly reduced risk for cancer mortality and cancer incidence.]

"Garland & Garland zeigten einen inversen Zusammenhang zwischen KolonkrebsMortalität und Sonneneinstrahlung und sie stellten die Hypothese auf, dass dieser Zusammenhang eine antikarzinogene Wirkung von Vitamin D reflektiert"

[Garland & Garland showed a inverse relation between colon cancer mortality and sunlight exposure and the developed the hypothesis, that this relation would reflect the anti-carcinogene effect of vitaminD.]

[Short] History of Fibromyalgia
http://www.fibrocenter.com/fibromyalgia-disease

Year	Event
1981	The first scientific study confirmed that symptoms and tender points could be found in the body.
1990	The American College of Rheumatology wrote the first set of guidelines to help diagnose fibromyalgia.
2005	The first guidelines for treating fibromyalgia pain were published by the American Pain Society.
2007	The first prescription medication was FDA-approved to manage fibromyalgia.

History of Fibromyalgia
https://www.news-medical.net/health/History-of-Fibromyalgia.aspx

"The condition has been known to mankind since the 1800’s when physicians wrote about a condition that leads to pain, fatigue and disturbed sleep. They called it muscular rheumatism and found no joint involvement."

"The disease was described clearly by Smythe in 1972 with the descriptions of the widespread pain and tender points."

Fibromyalgia Medications
https://www.news-medical.net/health/Fibromyalgia-Medications.aspx

"Fibromyalgia is a widespread pain disorder that affects females more than males. The condition as of now has no cure and is mainly treated symptomatically."

"Several medications, however, have been found to be useful in fibromyalgia. Some of these include:

• Pain relievers
• Antidepressants
• Tranquillizers and sedatives
• Muscle relaxing agents
• Anti-seizure medications
• Neuroleptics

"

No healing, only syptomatic "treatment" brings the big profit!

You can also dumb Yourself by looking at the results of "studies" and detect which one serves the interest of pharma and which one is honestly scientific! Who really needs that system of "perfect" dumbification?

Serum 25-OH vitamin D levels in patients with fibromyalgia.
Tandeter H1, Grynbaum M, Zuili I, Shany S, Shvartzman P.
Isr Med Assoc J. 2009 Jun;11(6):339-42.
https://www.ncbi.nlm.nih.gov/pubmed/19697583

"CONCLUSIONS:
We found no association between fibromyalgia and low 25OHD levels as previously suggested in other studies."

The relation between vitamin D deficiency and fibromyalgia syndrome in women.
https://www.ncbi.nlm.nih.gov/pubmed/21894355
Matthana MH1. Saudi Med J. 2011 Sep;32(9):925-9.

"CONCLUSION:

Vitamin D deficiency has to be considered in the management of fibromyalgia syndrome."

The Relationship Between Balance and Vitamin 25(OH)D in Fibromyalgia Patients
M Kasapoğlu Aksoy et al. Mod Rheumatol 1-7. 2016 Dec 09.
https://www.ncbi.nlm.nih.gov/labs/articles/27846770/

"CONCLUSION: It was observed that low vitamin D levels affected balance in both FMS group and healthy control group. It should be kept in mind that vitamin D level is likely to negatively affect balance and VAS values in FMS."

Abstracts Accepted for Publication
Fibromyalgia and pain in rheumatic diseases
D. Solmaz1, O. Avci2, B.C. Yalcin2, S.P. Kara2, M. Oran2
http://ard.bmj.com/content/74/Suppl_2/1215.1

"Conclusions

Vitamin D deficiency may contribute disease severity, fatigue and disturbances in health quality in FMS patients. Based on this, in FMS screening the level of vitamin D and correction may be helpful in symptom control."

From the same trash bin of NCBI You can find some pearls. :-)

Consider, that no one talks about the reasons of the epidemic vitaminD deficiency. No one has any hint about SRM, TAI, Tropospheric Water Grabbing, global climate control and geophysical warfare. They behave like hamsters in their cages.

Vitamin D and the Immune System
J Investig Med. 2011 Aug; 59(6): 881–886. doi: 10.231/JIM.0b013e31821b8755
PMCID: PMC3166406 NIHMSID: NIHMS291217
Cynthia Aranow, MD, Investigator
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/

"Conclusions

Vitamin D has important functions beyond those of calcium and bone homeostasis which include modulation of the innate and adaptive immune responses. Vitamin D deficiency is prevalent in autoimmune disease. Cells of the immune system are capable of synthesizing and responding to vitamin D. Immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D suggesting that the beneficial effects of supplementing vitamin D deficient individuals with autoimmune disease may extend beyond effects on bone and calcium homeostasis."

Vitamin D: The “sunshine” vitamin
J Pharmacol Pharmacother. 2012 Apr-Jun; 3(2): 118–126.
doi: 10.4103/0976-500X.95506 PMCID: PMC3356951 Rathish Nair and Arun Maseeh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/

"CONCLUSION
Numbers of people with VDD are continuously increasing; the importance of this hormone in overall health and the prevention of chronic diseases are at the forefront of research. VDD is very common in all age groups. Very few foods contain vitamin D therefore guidelines recommended supplementation of vitamin D at tolerable UL levels. It is also suggested to measure the serum 25-hydroxyvitamin D level as the initial diagnostic test in patients at risk for deficiency. Treatment with either vitamin D2 or vitamin D3 is recommended for the deficient patients."

Vitamin D deficiency: a worldwide problem with health consequences.
https://www.ncbi.nlm.nih.gov/pubmed/18400738
Am J Clin Nutr. 2008 Apr;87(4):1080S-6S. Holick MF1, Chen TC.

"Abstract


Vitamin D deficiency is now recognized as a pandemic. The major cause of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major source of vitamin D for most humans. Very few foods naturally contain vitamin D, and foods that are fortified with vitamin D are often inadequate to satisfy either a child's or an adult's vitamin D requirement. Vitamin D deficiency causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults. Vitamin D deficiency has been associated with increased risk of common cancers, autoimmune diseases, hypertension, and infectious diseases. A circulating level of 25-hydroxyvitamin D of >75 nmol/L, or 30 ng/mL, is required to maximize vitamin D's beneficial effects for health. In the absence of adequate sun exposure, at least 800-1000 IU vitamin D3/d may be needed to achieve this in children and adults. Vitamin D2 may be equally effective for maintaining circulating concentrations of 25-hydroxyvitamin D when given in physiologic concentrations."

Vitamin D deficiency is associated with anxiety and depression in fibromyalgia.
Armstrong DJ1, Meenagh GK, Bickle I, Lee AS, Curran ES, Finch MB.
Clin Rheumatol. 2007 Apr;26(4):551-4. Epub 2006 Jul 19.
https://www.ncbi.nlm.nih.gov/pubmed/16850115

"Abstract

Fibromyalgia is a complex problem in which symptoms of anxiety and depression feature prominently. Low levels of vitamin D have been frequently reported in fibromyalgia, but no relationship was demonstrated with anxiety and depression. ...Vitamin D deficiency is common in fibromyalgia and occurs more frequently in patients with anxiety and depression. The nature and direction of the causal relationship remains unclear, but there are definite implications for long-term bone health."

Vitamin D deficiency in women with fibromyalgia in Saudi Arabia.
Abokrysha NT1. Pain Med. 2012 Mar;13(3):452-8. doi: 10.1111/j.1526-4637.2011.01304.x. Epub 2012 Jan 5. Department of Neurology, Cairo University, Kaser Al-Aini Hospital, Al-Manyal, Cairo, Egypt. nhtaha@yahoo.com
https://www.ncbi.nlm.nih.gov/pubmed/22221390

"CONCLUSION:
Vitamin D deficiency is often seen in patients diagnosed with fibromyalgia in our population. This was equally true in veiled and nonveiled, but conservatively dressed populations. Effective treatment with high-dose vitamin D could lead to resolution of almost all symptoms. Further study of these populations and fortification of foods with vitamin D may be essential."

Vitamin D deficiency in Fibromyalgia
Shaheen Ayuob Bhatty, Niaz Ahmed Shaikh, Muhammad Irfan, Syed Muhammad Kashif, Aneel Sham Vaswani, Aneel Sumbhai, Gunpat ( Medical Unit One, Civil Hospital Karachi. ) November, 2010 >>
http://www.jpma.org.pk/full_article_text.php?article_id=2395

"Conclusion
Vitamin D Deficiency is frequently seen in patients diagnosed as fibromyalgia and nonspecific musculoskeletal pain in our population. Although the sample size of the study is small, but the figures are so alarming that it is an eye opener towards the need of a population based study , including normal population as well as those presenting with musculoskeletal pain. There is also a need to look into the factors contributing to vitamin D deficiency in our younger population as now it is not only considered as a culprit to bone disease but also common diseases like Diabetes, Hypertension and Heart disease which is already a burden on our health projects. More studies are needed to see the optimum levels of vitamin D in our population to prevent the different health consequences."

Hypovitaminosis D May Be A Factor In Fibromyalgia And Other Chronic Pain Disorders
https://fibromyalgianewstoday.com/2015/10/13/hypovitaminosis-d-may-factor-fibromyalgia-chronic-pain-disorders/

5. Psoriasis

Symptom orientation: Psoriasis - A collection of scientific studies!
https://geoarchitektur.blogspot.com/p/symptom-orientation-psoriasis.html

6. Multiple Sclerosis

7. Osteamalacia

Symptom orientation: Multiple Sclerosis - A collection of scientific studies!
https://geoarchitektur.blogspot.com/p/symptom-orientation-multiple-sclerosis.html

8. More about VitaminD

Symptom orientation: More about VitaminD - A collection of scientific sources!
https://geoarchitektur.blogspot.com/p/symptom-orientation-more-about-vitamind.html